Personalised privacy in pervasive and ubiquitous systems

Our world is edging closer to the realisation of pervasive systems and their integration in our everyday life. While pervasive systems are capable of offering many benefits for everyone, the amount and quality of personal information that becomes available raise concerns about maintaining user privacy and create a real need to reform existing privacy practices and provide appropriate safeguards for the user of pervasive environments. This thesis presents the PERSOnalised Negotiation, Identity Selection and Management (PersoNISM) system; a comprehensive approach to privacy protection in pervasive environments using context aware dynamic personalisation and behaviour learning. The aim of the PersoNISM system is twofold: to provide the user with a comprehensive set of privacy protecting tools and to help them make the best use of these tools according to their privacy needs. The PersoNISM system allows users to: a) configure the terms and conditions of data disclosure through the process of privacy policy negotiation, which addresses the current “take it or leave it” approach; b) use multiple identities to interact with pervasive services to avoid the accumulation of vast amounts of personal information in a single user profile; and c) selectively disclose information based on the type of information, who requests it, under what context, for what purpose and how the information will be treated. The PersoNISM system learns user privacy preferences by monitoring the behaviour of the user and uses them to personalise and/or automate the decision making processes in order to unburden the user from manually controlling these complex mechanisms. The PersoNISM system has been designed, implemented, demonstrated and evaluated during three EU funded projects

Ionization electron signal processing in single phase LArTPCs. Part I. Algorithm Description and quantitative evaluation with MicroBooNE simulation

We describe the concept and procedure of drifted-charge extraction developed in the MicroBooNE experiment, a single-phase liquid argon time projection chamber (LArTPC). This technique converts the raw digitized TPC waveform to the number of ionization electrons passing through a wire plane at a given time. A robust recovery of the number of ionization electrons from both induction and collection anode wire planes will augment the 3D reconstruction, and is particularly important for tomographic reconstruction algorithms. A number of building blocks of the overall procedure are described. The performance of the signal processing is quantitatively evaluated by comparing extracted charge with the true charge through a detailed TPC detector simulation taking into account position-dependent induced current inside a single wire region and across multiple wires. Some areas for further improvement of the performance of the charge extraction procedure are also discussed. Keywords: MicroBooNE, Signal Processing, Deconvolution, ROIUnited States. Department of Energy. High Energy Physics DivisionNational Science Foundation (U.S.)Swiss National Science FoundationScience and Technology Facilities Council (Great Britain)Royal Society (Great Britain

The power of peers in GTA development of practice: evaluation of an equal-status teaching observation project

Peer observation of teaching is a well-established professional development practice and can occur through a range of different activities (e.g., micro-teaching, lesson study, performance reviews, etc.). There is evidence that these various activities are being increasingly used to support Graduate Teaching Assistants (GTAs). This paper reports the findings of a pilot project that implemented equal-status, interdisciplinary and developmental peer observations. As a collaborative project, it was co-designed and evaluated by eight GTAs and an academic developer. Our observation framework involved GTAs’ undertaking the observee and observer roles and retaining five of six identified dimensions of control. The findings show that the observation experiences encouraged both new and experienced GTAs to take a self-reflective and critical stance to their teaching and disciplinary approaches. This confirms the value of GTAs’ experiencing the observer role and their exposure to other disciplinary environments. The post-observation ‘learning conversations’ provided significant opportunities for GTAs to discuss and reflect on their practice contexts and experiences together. This represents an effective example of peer supported learning, which also reduces the sense of isolation that GTAs often experience

Role of CD14+ monocyte-derived oxidised mitochondrial DNA in the inflammatory interferon type 1 signature in juvenile dermatomyositis

OBJECTIVES: To define the host mechanisms contributing to the pathological interferon (IFN) type 1 signature in Juvenile dermatomyositis (JDM). METHODS: RNA-sequencing was performed on CD4+, CD8+, CD14+ and CD19+ cells sorted from pretreatment and on-treatment JDM (pretreatment n=10, on-treatment n=11) and age/sex-matched child healthy-control (CHC n=4) peripheral blood mononuclear cell (PBMC). Mitochondrial morphology and superoxide were assessed by fluorescence microscopy, cellular metabolism by 13C glucose uptake assays, and oxidised mitochondrial DNA (oxmtDNA) content by dot-blot. Healthy-control PBMC and JDM pretreatment PBMC were cultured with IFN-α, oxmtDNA, cGAS-inhibitor, TLR-9 antagonist and/or n-acetyl cysteine (NAC). IFN-stimulated gene (ISGs) expression was measured by qPCR. Total numbers of patient and controls for functional experiments, JDM n=82, total CHC n=35. RESULTS: Dysregulated mitochondrial-associated gene expression correlated with increased ISG expression in JDM CD14+ monocytes. Altered mitochondrial-associated gene expression was paralleled by altered mitochondrial biology, including 'megamitochondria', cellular metabolism and a decrease in gene expression of superoxide dismutase (SOD)1. This was associated with enhanced production of oxidised mitochondrial (oxmt)DNA. OxmtDNA induced ISG expression in healthy PBMC, which was blocked by targeting oxidative stress and intracellular nucleic acid sensing pathways. Complementary experiments showed that, under in vitro experimental conditions, targeting these pathways via the antioxidant drug NAC, TLR9 antagonist and to a lesser extent cGAS-inhibitor, suppressed ISG expression in pretreatment JDM PBMC. CONCLUSIONS: These results describe a novel pathway where altered mitochondrial biology in JDM CD14+ monocytes lead to oxmtDNA production and stimulates ISG expression. Targeting this pathway has therapeutical potential in JDM and other IFN type 1-driven autoimmune diseases

Habitat features and their influence on the restoration potential of marine habitats in Europe

To understand the restoration potential of degraded habitats, it is important to know the key processes and habitat features that allow for recovery after disturbance. As part of the EU (Horizon 2020) funded MERCES project, a group of European experts compiled and assessed current knowledge, from both past and ongoing restoration efforts, within the Mediterranean Sea, the Baltic Sea, and the North-East Atlantic Ocean. The aim was to provide an expert judgment of how different habitat features could impact restoration success and enhance the recovery of marine habitats. A set of biological and ecological features (i.e., life-history traits, population connectivity, spatial distribution, structural complexity, and the potential for regime shifts) were identified and scored according to their contribution to the successful accomplishment of habitat restoration for five habitats: seagrass meadows, kelp forests, Cystoseira macroalgal beds, coralligenous assemblages and cold-water coral habitats. The expert group concluded that most of the kelp forests features facilitate successful restoration, while the features for the coralligenous assemblages and the cold-water coral habitat did not promote successful restoration. For the other habitats the conclusions were much more variable. The lack of knowledge on the relationship between acting pressures and resulting changes in the ecological state of habitats is a major challenge for implementing restoration actions. This paper provides an overview of essential features that can affect restoration success in marine habitats of key importance for valuable ecosystem services

Current marine pressures and mechanisms driving changes in marine habitats

Human activities and the resultant pressures they place on the marine environment have been widely demonstrated to contribute to habitat degradation, therefore, their identification and quantification is an essential step towards any meaningful restoration effort. The overall scope of MERCES Deliverable 1.2 is to review current knowledge regarding the major marine pressures placed upon marine ecosystems in EU waters and the mechanisms by which they impact habitats in order to determine potential restoration pathways. An understanding of their geographical distribution is critical for any local assessment of degradation, as well as for planning conservation and restoration actions. This information would ideally be in the form of maps, which: (a) compile single or multiple activities and pressures over broad scales, integrating and visualizing available data and allowing direct identification of aggregations as well as gaps and (b) may be overlaid with habitat maps (or any other map layer containing additional information), thus combining different data levels and producing new information to be used for example when implementing EU policies. The deliverable also documents typical example habitat case studies, the prominent impacts and consequences of activities and pressures towards the identification of possible restoration or mitigation actions. Finally the deliverable discusses pressures, assessments, marine spatial planning and blue growth potential. Activities and pressures are used in a strict sense, where marine activities are undertaken to satisfy the needs of societal drivers (e.g. aquaculture or tourism) and pressures are considered to be the mechanism through which an activity has an actual or potential effect on any part of the ecosystem (e.g. for demersal trawling activity, one pressure would be abrasion of the seabed). Habitats are addressed using a nested approach from large-scale geological features (e.g. shallow soft bottoms) to species-characterised habitats (e.g. Posidonia meadows) because of the way they are referred to in current policy documents which lack standard and precise definitions